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Coenzyme Q10

Heart health

Coenzyme Q10 helps to maintain a healthy cardiovascular system. There is 

evidence of CoQ10 deficiency in heart failure. Recently, CoQ10 plasma 

concentrations have been demonstrated as an independent predictor of mortality 

in chronic heart failure, CoQ10 deficiency being detrimental to the long-term 

prognosis of chronic heart failure.[40][citation needed] CoQ10 is available as 

medicine in several European countries, but is in these countries also 

available as a food supplement. Oxidation of the circulating LDL is thought to 

play a key role in the pathogenesis of atherosclerosis, which is the 

underlying disorder leading to heart attack and ischemic strokes[41][42][43] 

and CHD. Studies in the last decade have demonstrated that the content of 

Ubiquinol in human LDL affords protection against the oxidative modifications 

of LDL themselves, thus lowering their atherogenic potency.

Blood pressure

There are several reports concerning the effect of CoQ10 on blood pressure in 

human studies.A recent (2007) meta-analysis of the clinical trials of CoQ10 

for hypertension reviewed all published trials of coenzyme Q10 for 

hypertension, and assessed overall efficacy, consistency of therapeutic 

action, and side-effect incidence. Meta-analysis was performed in 12 clinical 

trials (362 patients) comprising three randomized controlled trials, one 

crossover study, and eight open-label studies. The meta-analysis concluded 

that coenzyme Q10 has the potential in hypertensive patients to lower systolic 

blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm 

Hg without significant side-effects.

Absorption

CoQ10 is a crystalline powder that is insoluble in water. Absorption follows 

the same process as that of lipids and the uptake mechanism appears to be 

similar to that of vitamin E, another lipid-soluble nutrient.This process in 

the human body involves the secretion of pancreatic enzymes and bile into the 

small intestines that facilitate emulsification and micelle formation that is 

required for the absorption of lipophilic substances.[13] Food intake (and the 

presence of lipids) stimulates bodily biliary excretion of bile acids and 

greatly enhances the absorption of CoQ10. Exogenous CoQ10 is absorbed from the 

small intestinal tract and is best absorbed if it is taken with a meal. Serum 

concentration of CoQ10 in fed condition is higher than in fasting conditions.