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Cranberry

Phytochemicals

Raw cranberries are a source of polyphenol antioxidants, phytochemicals 

under active research for possible benefits to the cardiovascular system 

and immune system, and as anti-cancer agents,[13][14] such as in isolated 

prostate cancer cells.[15] Although polyphenols have antioxidant effects in 

vitro, they can act as pro-oxidants in others.[clarification needed] In 

addition, it is uncertain whether polyphenols and flavonoids account for 

the benefits of diets rich in plant-derived foods.[14]

Cranberry juice contains a high molecular weight non-dializable material 

that might inhibit formation of plaque by Streptococcus mutans pathogens 

that cause tooth decay.[16] Cranberry juice components also may possibly 

influence formation of kidney stones.[17][18]

One study compared cranberries with twenty other fruits, showing that 

cranberries had a high amount of total polyphenols.[19] Cranberry tannins 

have laboratory evidence for anti-clotting properties and may prevent 

recurring urinary tract infections in women.[20] Raw cranberries and 

cranberry juice are abundant food sources of flavonoids such as 

proanthocyanidins, flavonols [21] and quercetin.[22][23] These compounds 

have shown possible activity as anti-cancer agents in vitro.[24][25][26]

[27][28] However, their effectiveness in humans has not been established, 

and is limited by poor absorption into cells and rapid excretion.

Potential anti-adhesion properties

There is potential benefit of cranberry juice consumption against bacterial 

infections in the urinary system. Laboratory research shows that a possible 

effect may occur from a component of the juice inhibiting bacterial 

attachment to the bladder and urethra.[29][30][31]

Although promising for anti-bacterial activity, long-term consumption of 

cranberry juice has not been proven to reduce urinary tract infections in 

whole populations. However, there is preliminary evidence for possible 

effects against urinary tract infections in women.[32] Similar applications 

have not been successfully proven in other clinical trials of consuming 

cranberry juice or tablets by people with spinal cord injury associated 

with bladder catheterization, neurogenic bladder or infrequent urination, 

any of which may be associated with increased susceptibility to bacterial 

infections.

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